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Cell Collective [3] is a modeling software that enables one to house dynamical biological data, build computational models, stimulate, break and recreate models. The development is led by Tomas Helikar, [4] a researcher within the field of computational biology. It is designed for biologists, students learning about computational biology ...
Carbon on Earth naturally occurs in two stable isotopes, with 98.9% in the form of 12 C and 1.1% in 13 C. [1] [8] The ratio between these isotopes varies in biological organisms due to metabolic processes that selectively use one carbon isotope over the other, or "fractionate" carbon through kinetic or thermodynamic effects. [1]
Diagram of the latent diffusion architecture used by Stable Diffusion The denoising process used by Stable Diffusion. The model generates images by iteratively denoising random noise until a configured number of steps have been reached, guided by the CLIP text encoder pretrained on concepts along with the attention mechanism, resulting in the desired image depicting a representation of the ...
The switches maintain the orderly progression of the cell cycle and act as checkpoints to ensure that each phase has been properly completed before progression to the next phase. [1] For example, Cdk, or cyclin dependent kinase , is a major control switch for the cell cycle and it allows the cell to move from G1 to S or G2 to M by adding ...
Coming from this bi-stable model, we can understand the mitotic transition as relying on hysteresis to drive it. Hysteresis is defined as the dependence of the state of a system on its history. The Novak–Tyson model is a mathematical model of cell cycle progression that predicts that irreversible transitions entering and exiting mitosis are ...
The intra-S Phase Checkpoint detects Double Strand Breaks (DSBs) through activation of ATR and ATM kinases. [12] In addition to facilitating DNA repair, active ATR and ATM stalls cell cycle progression by promoting degradation of CDC25A, a phosphatase that removes inhibitory phosphate residues from CDKs. [ 12 ]
The G1/S checkpoint, G2/M checkpoint, and the checkpoint between metaphase and anaphase all monitor for DNA damage and halt cell division by inhibiting different cyclin-CDK complexes. The p53 tumor-suppressor protein plays a crucial role at the G1/S checkpoint and the G2/M checkpoint. Activated p53 proteins result in the expression of many ...
By replenishing lost electrons with electrons from the splitting of water, photosystem II provides the electrons for all of photosynthesis to occur. The hydrogen ions (protons) generated by the oxidation of water help to create a proton gradient that is used by ATP synthase to generate ATP .