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Eight are known to cause Lyme disease or Borreliosis. [6] The major Borrelia species causing Lyme disease are Borrelia burgdorferi, Borrelia afzelii, and Borrelia garinii. [23] All species that cause Lyme disease are referred to collectively as B. burgdorferi sensu lato, [10] while B. burgdorferi itself is specified as B. burgdorferi sensu stricto.
Lyme disease, also known as Lyme borreliosis, is a tick-borne disease caused by species of Borrelia bacteria, transmitted by blood-feeding ticks in the genus Ixodes. [4] [9] [10] The most common sign of infection is an expanding red rash, known as erythema migrans (EM), which appears at the site of the tick bite about a week afterwards. [1]
A number of alternative health products are promoted for chronic Lyme disease, [8] of which possibly the most controversial and harmful is long-term antibiotic therapy, particularly intravenous antibiotics. [9] [10] Recognised authorities advise against long-term antibiotic treatment for Lyme disease, even where some symptoms persist post ...
The genomic variations have direct implications on the clinical symptoms of tick-borne Lyme disease. For example, B. burgdorferi s.s.’s tick-borne Lyme disease may manifest with arthritis-like symptoms. [9] In contrast, B. garinii’s tick-borne Lyme disease may cause an infection of the central nervous system. [9]
Borrelia mayonii was identified as a sensu lato (broad sense), genospecies (Bbsl) of the known microbe, Borrelia burgdorferi. [2] A genospecies is a cluster of organisms with similar core genes that usually does not undergo genetic recombination with diverged organisms. [3]
Borrelia burgdorferi is a bacterial species of the spirochete class in the genus Borrelia, and is one of the causative agents of Lyme disease in humans. [1] [2] Along with a few similar genospecies, some of which also cause Lyme disease, it makes up the species complex of Borrelia burgdorferi sensu lato.
Major US medical authorities, including the Infectious Diseases Society of America, [5] the American Academy of Neurology, [6] and the National Institutes of Health, [7] are careful to distinguish the diagnosis and treatment of "patients who have had well-documented Lyme disease and who remain symptomatic for many months to years after ...
This rash was known as erythema chronicum migrans, the skin rash found in early-stage Lyme disease. [ 18 ] In the 1920s, French physicians Garin and Bujadoux described a patient with meningoencephalitis, painful sensory radiculitis, and erythema migrans following a tick bite, and they postulated the symptoms were due to a spirochetal infection.
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