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Rubidium-82 (82 Rb) is a radioactive isotope of rubidium. 82 Rb is widely used in myocardial perfusion imaging . This isotope undergoes rapid uptake by myocardiocytes , which makes it a valuable tool for identifying myocardial ischemia in Positron Emission Tomography (PET) imaging.
Cardiac PET (or cardiac positron emission tomography) is a form of diagnostic imaging in which the presence of heart disease is evaluated using a PET scanner. Intravenous injection of a radiotracer is performed as part of the scan. Commonly used radiotracers are Rubidium-82, Nitrogen-13 ammonia and Oxygen-15 water. [1]
Rubidium-82 chloride is a form of rubidium chloride containing a radioactive isotope of rubidium. It is marketed under the brand name Cardiogen-82 by Bracco Diagnostics for use in Myocardial perfusion imaging . [ 1 ]
This limitation restricts clinical PET primarily to the use of tracers labelled with fluorine-18, which has a half-life of 110 minutes and can be transported a reasonable distance before use, or to rubidium-82 (used as rubidium-82 chloride) with a half-life of 1.27 minutes, which is created in a portable generator and is used for myocardial ...
Many radionuclides used for myocardial perfusion imaging, including rubidium-82, technetium-99m and thallium-201 have similar typical effective doses (15-35 mSv). [17] The Cardiac PET tracer nitrogen-13 ammonia, though less widely available, may offer significantly reduced doses (2 mSv).
This is a list of positron emission tomography (PET) radiotracers. ... [82 Rb] Rubidium-82 chloride [11 C] Acetate (Also used in oncology) Neurology
Other than 87 Rb, the longest-lived radioisotopes are 83 Rb with a half-life of 86.2 days, 84 Rb with a half-life of 33.1 days, and 86 Rb with a half-life of 18.642 days. All other radioisotopes have half-lives less than a day. 82 Rb is used in some cardiac positron emission tomography scans to assess myocardial perfusion. It has a half-life of ...
The positron quickly annihilates with an electron, producing two gamma rays of about 511 keV which are detectable using a PET scanner. [citation needed] Of several available PET tracers for quantification of myocardial blood flow (MBF), 82 Rb, 13 NH 3, and H 2 15 O are most commonly used. (see the table below).