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H. pylori is able to adhere to the surface of the phagocytes and impede their action. This is responded to by the phagocyte in the generation and release of oxygen metabolites into the surrounding space. H. pylori can survive this response by the activity of catalase at its attachment to the phagocytic cell surface. Catalase decomposes hydrogen ...
The role of H. pylori in functional dyspepsia is controversial, and treatment for H. pylori may not lead to complete improvement of a patient's dyspepsia. [6] However, a recent systemic review and meta-analysis of 29 studies published in 2022 suggests that successful treatment of H. pylori modestly improves indigestion symptoms. [18]
In 1999, a review of existing studies found that, on average, 40% of GERD patients also had H. pylori infection. [39] The eradication of H. pylori can lead to an increase in acid secretion, [ 40 ] leading to the question of whether H. pylori -infected GERD patients are any different from non-infected GERD patients.
Secondary constipation, which is due to another cause, such as chronic conditions, like Type 2 diabetes, poor dietary choices or neurological conditions that may impact intestinal motility
Gastritis caused by H. pylori infection is termed Helicobacter pylori induced gastritis, and listed as a disease in ICD11. [6] [7] More than 80% of individuals infected with the bacterium are asymptomatic and it has been postulated that it may play an important role in the natural stomach ecology. [17]
[3] [4] [5] Its usefulness in people infected by H. pylori is limited. [3] It is used by mouth (for upper GIT ulcers) and rectally (for radiation proctitis). [3] [5] Common side effects include constipation. [3] Serious side effects may include bezoar formation and encephalopathy. [6] Use appears to be safe in pregnancy and breastfeeding. [6]
Several epidemiological studies have demonstrated a moderate correlation between dyspepsia in the general population and female sex, smoking, non-steroidal anti-inflammatory medication use, and H pylori infection. [13] In one long-term investigation, a high body mass index was an independent predictor of the emergence of functional dyspepsia. [14]
Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass. [2] The stool is often hard and dry. [4] Other symptoms may include abdominal pain, bloating, and feeling as if one has not completely passed the bowel movement. [3]