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Dysplasia is the earliest form of precancerous lesion recognizable in a biopsy. Dysplasia can be low-grade or high-grade. High-grade dysplasia may also be referred to as carcinoma in situ. Invasive carcinoma, usually simply called cancer, has the potential to invade and spread to surrounding tissues and structures, and may eventually be lethal.
In HGPIN, the basal cell layer is disrupted but present. PIN is primarily found in the peripheral zone of the prostate (75-80%), rarely in the transition zone (10-15%) and very rarely in the central zone (5%), a distribution that parallels the zonal distribution for prostate carcinoma. [7]
M8201/2 Cribiform carcinoma in situ (C50._) Ductal carcinoma in situ, cribiform type; M8201/3 Cribiform carcinoma, NOS Ductal carcinoma, cribiform type; M8202/0 Microcystic adenoma (C25._) M8204/0 Lactating adenoma; M8210/0 Adenomatous polyp, NOS Polypoid adenoma; M8210/2 Adenocarcinoma in situ in adenomatous polyp Adenocarcinoma in situ in ...
The full chapter can be found on pages 101 to 144 of Volume 1, which contains all (sub)categories of the ICD-9. Volume 2 is an alphabetical index of Volume 1. Both volumes can be downloaded for free from the website of the World Health Organization. See here for a tabular overview of primary, secondary, in situ, and benign neoplasms.
Potentially-malignant neoplasms include carcinoma in situ. They are localised, and do not invade and destroy but in time, may transform into cancer. Malignant neoplasms are commonly called cancer. They invade and destroy the surrounding tissue, may form metastases and, if untreated or unresponsive to treatment, will generally prove fatal.
The term dysplasia is typically used when the cellular abnormality is restricted to the originating tissue, as in the case of an early, in-situ neoplasm. [ citation needed ] Dysplasia, in which cell maturation and differentiation are delayed, can be contrasted with metaplasia , in which cells of one mature, differentiated type are replaced by ...
Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder. Abnormal growth of prostate tissue is usually detected through screening tests, typically blood tests that check for prostate-specific antigen (PSA) levels. Those with high levels of PSA in their blood are at increased ...
A histopathologic diagnosis of prostate cancer is the discernment of whether there is a cancer in the prostate, as well as specifying any subdiagnosis of prostate cancer if possible. The histopathologic subdiagnosis of prostate cancer has implications for the possibility and methodology of any subsequent Gleason scoring . [ 1 ]