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5-HTP is produced from the amino acid tryptophan through the action of the enzyme tryptophan hydroxylase. Tryptophan hydroxylase is one of the biopterin-dependent aromatic amino acid hydroxylases. Production of 5-HTP is the rate-limiting step in 5-HT (serotonin) synthesis. 5-HTP is normally rapidly converted to 5-HT by amino acid decarboxylase. [1]
However, the tryptophan derivative 5-HTP (5-hydroxytryptophan), used in the treatment of depression, raises blood serotonin level considerably [citation needed]. It has yet to be reported to be associated with valve disease or other fibrosis, but for the previous theoretical reasons, it has been suggested as a possible danger. [citation needed]
5-HTP is rapidly absorbed with a t max of ≈1.5 h, and rapidly eliminated with a half-life of ≈1.5 – 2 h. Co-administration of a decarboxylase inhibitor (e.g., carbidopa, benserazide ) doubles the half-life of 5-HTP to ≈ 3 – 4 h , [ 37 ] [ 34 ] and enhances exposure several-fold, depending on the dosing regimen.
Heart disease is the No. 1 cause of death in the U.S. Yet, according to the American Heart Association, half of Americans are unaware of this sobering statistic. The good news is that a diet ...
A 2021 study linking strawberries to heart health found eating 2.5 servings of strawberries per day for four weeks improved LDL cholesterol levels in adults with obesity and high cholesterol.
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. [ 1 ] [ 2 ] [ 3 ] They mediate both excitatory and inhibitory neurotransmission .
Rich in fiber, vitamins and minerals, such as magnesium, copper and manganese, nuts provide another great plant-based protein source. Eating walnuts, in particular, can help reduce blood pressure ...
Carbidopa/oxitriptan (developmental code name EVX-101), or carbidopa/5-hydroxytryptophan (carbidopa/5-HTP), is a combination of 5-hydroxytryptophan (oxitriptan), a serotonin precursor, and carbidopa, a peripherally selective aromatic L-amino acid decarboxylase inhibitor, which is under development as an antidepressant for the treatment of depressive disorders. [1]
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