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Diclofenac, sold under the brand name Voltaren among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. [ 6 ] [ 9 ] It can be taken orally (swallowed by mouth), inserted rectally as a suppository , injected intramuscularly , injected intravenously , applied to the skin topically ...
Apart from blood sugar ... (dogs); 31% (rats) 86.20%: 1.5: 13.2 (10 mg dose); 13.3h (25 mg dose) ... With dose-dependent concentrations the half-life is about ...
Absorption half-life 1 h, elimination half-life 12 h. Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
In this situation it is generally uncommon to talk about half-life in the first place, but sometimes people will describe the decay in terms of its "first half-life", "second half-life", etc., where the first half-life is defined as the time required for decay from the initial value to 50%, the second half-life is from 50% to 25%, and so on.
Elimination half-life: The time required for the concentration of the drug to reach half of its original value. 12 h Elimination rate constant: The rate at which a drug is removed from the body.
Alternatively, since the radioactive decay contributes to the "physical (i.e. radioactive)" half-life, while the metabolic elimination processes determines the "biological" half-life of the radionuclide, the two act as parallel paths for elimination of the radioactivity, the effective half-life could also be represented by the formula: [1] [2]
Tritium (from Ancient Greek τρίτος (trítos) 'third') or hydrogen-3 (symbol T or 3 H) is a rare and radioactive isotope of hydrogen with a half-life of ~12.3 years. The tritium nucleus (t, sometimes called a triton) contains one proton and two neutrons, whereas the nucleus of the common isotope hydrogen-1 (protium) contains one proton and no neutrons, and that of non-radioactive hydrogen ...
In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1]