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On one hand, doxycycline has been shown to be one of the only successful treatments for M. perstans, and could facilitate the eradication of filarial parasites. However, some scientists argue that the treatment of filariasis with doxycycline may select worms that will have already integrated Wolbachia genes into their genome, which could ...
Doxycycline is a broad-spectrum antibiotic of the tetracycline class used in the treatment of infections caused by bacteria and certain parasites. [1] It is used to treat bacterial pneumonia , acne , chlamydia infections , Lyme disease , cholera , typhus , and syphilis . [ 1 ]
In 2003, the common antibiotic doxycycline was suggested for treating elephantiasis. [21] Filarial parasites have symbiotic bacteria in the genus Wolbachia , which live inside the worm and seem to play a major role in both its reproduction and the development of the disease.
Tetracyclines are generally used in the treatment of infections of the urinary tract, respiratory tract, and the intestines and are also used in the treatment of chlamydia, especially in patients allergic to β-lactams and macrolides; however, their use for these indications is less popular than it once was due to widespread development of resistance in the causative organisms.
Broad-spectrum antiparasitics, analogous to broad-spectrum antibiotics for bacteria, are antiparasitic drugs with efficacy in treating a wide range of parasitic infections caused by parasites from different classes.
Drawbacks to using doxycycline include bacterial resistance and patient compliance because of a longer treatment regimen and the emergence of doxycycline-resistant Wolbachia. However, in the study over 97% of the patients complied with treatment, so it poses as a promising treatment for onchocerciasis while avoiding complications associated ...
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