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The typical threshold for treatment is CIN 2+, although a more restrained approach may be taken for young persons and pregnant women. Treatment for higher-grade CIN involves removal or destruction of the abnormal cervical cells by cryocautery, electrocautery, laser cautery, loop electrical excision procedure (LEEP), or cervical conization. [21]
The loop electrosurgical excision procedure (LEEP) is one of the most commonly used approaches to treat high grade cervical dysplasia (CIN II/III, HGSIL) and early stage cervical cancer discovered on colposcopic examination. In the UK, it is known as large loop excision of the transformation zone (LLETZ).
This disease can progress to invasive cancer (squamous cell carcinoma) of the cervix. Cervical squamous intraepithelial lesion (SIL), previously called cervical intraepithelial neoplasia (CIN), is a form of dysplasia that can progress to cervical cancer. The term carcinoma in situ may be used interchangeably with high-grade SIL. [8]
LEEP cone biopsy displaying normal cervical epithelium (far left) progressing to borderline koilocytosis, to LSIL, and to HSIL (far right). A squamous intraepithelial lesion (SIL) is an abnormal growth of epithelial cells on the surface of the cervix, commonly called squamous cells.
High grade anal intraepithelial neoplasia. Progression of pancreatic intraepithelial neoplasia, including mutations. [1] Cervical intraepithelial neoplasia (CIN), spanning a bit more than 2/3 of the thickness of the cervical epithelium. Intraepithelial neoplasia (IEN) is the development of a benign neoplasia or high-grade dysplasia in an ...
Dyskaryosis is used synonymously with dysplasia, which is the more common term. The term "dyskaryosis" is not to be confused with "dyskeratosis". "Dyskaryosis" is a term used for all squamous mucosal surfaces and commonly used for the uterine cervix condition in which some of the epithelial cells near the external orifice show abnormalities in ...
High-grade squamous intraepithelial lesion (HSIL or HGSIL) indicates moderate or severe cervical intraepithelial neoplasia or carcinoma in situ. It is usually diagnosed following a Pap test. In some cases these lesions can lead to invasive cervical cancer, if not followed appropriately. [citation needed] HSIL does not mean that cancer is present.
CIN 1, also known as low-grade SIL, is the most benign finding. This represents very few atypical cells found, and generally, these cells will revert to normal. [14] CIN 2 and 3, also known as high-grade SIL, indicate that more tissue looks abnormal. These changes represent a higher likelihood of progression to cancer.