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Conventional DMARDs are known to be the first-line treatment for rheumatoid arthritis. [9] Treatment can be a monotherapy or in combination with other anti-arthritic medications. Common DMARDs include oral methotrexate, leflunomide, or sulfasalazine. Conventional DMARDs have a slow onset of action and can take 2–3 months to exhibit effect. [9]
Rofecoxib was approved by the FDA to treat osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, acute pain conditions, migraine, and dysmenorrhea. When it was marketed, it gained widespread acceptance among physicians treating patients with arthritis and other conditions causing chronic or acute pain. [1]
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. [1] It typically results in warm, swollen, and painful joints. [ 1 ] Pain and stiffness often worsen following rest. [ 1 ]
August 1950—An arthritis program was established within the National Institute of Arthritis and Metabolic Diseases under Public Law 81-692. May 1972—P.L. 92-305 renamed the institute the National Institute of Arthritis, Metabolism, and Digestive Diseases.
There is no known cure for arthritis and rheumatic diseases. Treatment options vary depending on the type of arthritis and include physical therapy, exercise and diet, orthopedic bracing, and oral and topical medications. [2] [82] Joint replacement surgery may be required to repair damage, restore function, or relieve pain. [2]
Over the years the Arthritis Foundation has invested over $500 million toward medical research for more effective treatments and ultimately a cure. [2] In addition, the organization advocates for changes to health care policies, legislation and government-funded research to improve the lives of individuals and families affected by arthritis.
In this stage there are two surgical treatment options; total wrist arthroplasty and total wrist arthrodesis. Total wrist arthrodesis is the standard surgical treatment for patients with stage IV wrist osteoarthritis. During this procedure the carpal bones are all fused together and are then fastened to the distal radius. [14]
Treatment can vary depending on the cause and severity of the condition. Physical therapy, acupuncture, and anti-inflammatory drugs are commonly used to treat the disease. In more severe cases, intra-articular corticosteroid injections or surgical joint replacement may be necessary. Joint drainage and antibiotics are used to treat septic arthritis.
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