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They have been designed to be similar to THC, [9] the natural cannabinoid with the strongest binding affinity to the CB 1 receptor, which is linked to the psychoactive effects or "high" of marijuana. [10] These synthetic analogs often have greater binding affinity and greater potency to the CB 1 receptors.
List of psychoactive substances and precursor chemicals derived from genetically modified organisms; List of psychoactive substances derived from artificial fungi biotransformation; List of substances used in rituals; Medicinal fungi
However, cannabis does not naturally contain significant amounts of THC. Instead, tetrahydrocannabinolic acid (THCA) is found naturally in raw and live cannabis and is non-intoxicating. Over time, THCA slowly converts to THC through a process of decarboxylation over the course of roughly a year, but can be sped up with exposure to high ...
CBN was the first cannabis compound to be isolated from cannabis extract in the late 1800s. Its structure and chemical synthesis were achieved by 1940 [ 34 ] , followed by some of the first pre-clinical research studies to determine the effects of individual cannabis-derived compounds in vivo . [ 35 ]
The following is a list of psychedelic drugs of various chemical classes, including both naturally occurring and synthetic compounds. Serotonergic psychedelics are usually considered the "classical" psychedelics [dubious – discuss], whereas the other classes are often seen as having only secondary psychedelic properties; nonetheless all of the compounds listed here are considered ...
Voacangine is similar in structure to ibogaine. It inhibits AChE. [161] [162] Dendrobine [163] Dendrobium nobile. Also contains phenanthrenes and dendrobine related alkaloids. Possibly Genistein and Apigenin. Zornia latifolia. Zornia latifolia is sometimes combined with synthetic cannabis. It may produce similar effects to cannabis.
Hexahydrocannabinol (HHC) is a hydrogenated derivative of tetrahydrocannabinol (THC). It is a naturally occurring phytocannabinoid that has rarely been identified as a trace component in Cannabis sativa, [1] [2] but can also be produced synthetically by firstly acid cyclization of cannabidiol and then hydrogenation of tetrahydrocannabinol.
Research has shown that Humulus lupulus (the plant that makes hops) and Cannabis sativa (also called hemp and marijuana) are closely related, [1] [a] and it may be possible to create novel cultivars of hops that express valuable chemicals similar to commercial hemp.