Search results
Results from the WOW.Com Content Network
Thalidomide is racemic; while S-thalidomide is the bioactive form of the molecule, the individual enantiomers can racemize to each other due to the acidic hydrogen at the chiral centre, which is the carbon of the glutarimide ring bonded to the phthalimide substituent. The racemization process can occur in vivo.
Feet of a baby born to a mother who had taken thalidomide while pregnant. In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as ...
Maio G., On the history of the Contergan (thalidomide) catastrophe in the light of drug legislation, Dtsch Med Wochenschr. 2001 October 19;126(42):1183-6.; Shah RR., Thalidomide, drug safety and early drug regulation in the UK, Adverse Drug React Toxicol Rev. 2001 Dec;20(4):199-255.
On Giant's Shoulders is a 1979 BBC television film about the early life of thalidomide victim Terry Wiles, with Wiles playing himself. The drama also starred Bryan Pringle and Judi Dench and won an Emmy Award in 1980. [1] [2]
David Leslie Mason OBE (born 15 March 1939) is a London art dealer and Thalidomide parent activist. He is the father of a daughter, Louise, disabled by thalidomide . Mason was educated at Highgate School , where he studied under Kyffin Williams .
The Committee on Safety of Medicines (CSM) was an independent advisory committee that advised the UK Licensing Authority on the quality, efficacy, and safety of medicines. Following the thalidomide tragedy of 1957 to 1961, in 1963 the government asked Sir Derrick Dunlop to set up a committee to investigate the control and introduction of new ...
Michaelina "Mikey" Argy [1] MBE (born 1962) is an English thalidomide survivor and activist. [2] [3] She is a past chair of the National Advisory Committee of the Thalidomide Trust, the organisation through which British thalidomide survivors receive financial support, [1] and is still involved in the media activities of the trust.
McBride published a letter in The Lancet, in December 1961, noting a large number of birth defects in children of patients who were prescribed thalidomide, [9] after a midwife named Sister Pat Sparrow first suspected the drug was causing birth defects in the babies of patients under his care at Crown Street Women's Hospital in Sydney. [10]