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In a large clinical trial, bradycardia (unusually slow heart rate) occurred in 2% and 5% of patients taking ivabradine at doses of 7.5 and 10 mg respectively (compared to 4.3% in those taking atenolol). [6] Headaches were reported in 2.6 to 4.8 percent of cases. [6]
The correlation between the severity of symptoms and measured ibuprofen plasma levels is weak. Toxic effects are unlikely at doses below 100 mg/kg, but can be severe above 400 mg/kg (around 150 tablets of 200 mg units for an average adult male); [47] however, large doses do not indicate the clinical course is likely to be lethal. [48]
Common side effects include headache, tiredness, trouble sleeping, abdominal pain, weight loss, and rash. [5] Serious side effects may include high blood lactate levels and enlargement of the liver. [7] Use of this medication during pregnancy does not appear to harm the fetus, but this has not been well studied. [1]
Ibuprofen/paracetamol, sold under the brand name Combogesic among others, is a fixed-dose combination of two medications, ibuprofen, a non-steroidal anti-inflammatory drug (NSAID); and paracetamol (acetaminophen), an analgesic and antipyretic. [6] It is available as a generic medication. [9] [10] [11]
The side effects for hydrocodone/ibuprofen are a combination of the side effects of the component drugs. Side effects experienced in more than 10% of the population taking the drug include: headache, drowsiness, dizziness, constipation, nausea, and dyspepsia. [5]
Midol, like other NSAID class of drugs, may have side effects for some, such as an increased risk of bleeding, kidney damage or negative effects on cardiovascular system. [7] The "Midol Complete" formulation consists of: Acetaminophen 500 mg (pain reliever) Caffeine 60 mg (stimulant) Pyrilamine maleate 15 mg (antihistamine)
Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting. [medical citation needed] In rare cases, chlorzoxazone may cause severe liver dysfunction. [3] On the other hand, chlorzoxazone may reduce the liver toxicity of acetaminophen by competitive inhibition. [4] It is available as a generic medication. [5]
The combination was first introduced as the name Trigesic, as the formula of 125 mg paracetamol, 230 mg aspirin, and 30 mg caffeine, in July 1950 by Squibb, which is now Bristol Myers Squibb, but was recalled in the following year due to several reports that the drug might cause blood dyscrasia. [5]
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