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Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin (RLC) is a protein that in humans is encoded by the MYL2 gene. [ 5 ] [ 6 ] This cardiac ventricular RLC isoform is distinct from that expressed in skeletal muscle ( MYLPF ), smooth muscle ( MYL12B ) and cardiac atrial ...
Structurally, myosin light chains belong to the EF-hand family, a large family of Ca 2+ - binding proteins. MLCs contain two Ca 2+ - binding EF-hand motifs. MLCs isoforms modulate the Ca 2+ of force transduction and cross-bridge kinetics. Myosin light chains (MLCs) can be broadly classified into two groups: Essential or alkali MLC (MLC1 or ELC),
Atrial Light Chain-2 (ALC-2) also known as Myosin regulatory light chain 2, atrial isoform (MLC2a) is a protein that in humans is encoded by the MYL7 gene. [ 5 ] [ 6 ] ALC-2 expression is restricted to cardiac muscle atria in healthy individuals, where it functions to modulate cardiac development and contractility .
Binding of calcium ion to this domain increases the affinity of MYLK binding to myosin light chain. This myosin binding domain is located at the C-Terminus end of the kinase. On the other side of the kinase at the N-Terminus end, sits the actin-binding domain, which allows MYLK to form interactions with actin filaments, keeping it in place. [4] [5]
228785 Ensembl ENSG00000101306 ENSMUSG00000027470 UniProt Q9H1R3 Q8VCR8 RefSeq (mRNA) NM_033118 NM_001081044 RefSeq (protein) NP_149109 NP_001074513 Location (UCSC) Chr 20: 31.82 – 31.83 Mb Chr 2: 152.75 – 152.76 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myosin light chain kinase 2 also known as MYLK2 is an enzyme which in humans is encoded by the MYLK2 gene. Function This ...
Myosin, light chain 12B, regulatory is a protein that in humans is encoded by the MYL12B gene. [1] The gene is also known as MLC-B and MRLC2. [1] The activity of nonmuscle myosin II is regulated by phosphorylation of a regulatory light chain, such as MYL12B. This phosphorylation results in higher ATPase activity and the assembly of myosin II ...
Massachusetts has the second-longest life expectancy in the country. Only 2.6% of the population is estimated to lack healthcare coverage, and in 2022, the American Lung Association reported that ...
In smooth muscle, a single gene [20]) codes for the heavy chains myosin II, but splice variants of this gene result in four distinct isoforms. [19] It also contains 4 myosin light chains (MLC), resulting in 2 per head, weighing 20 (MLC 20) and 17 (MLC 17) kDa. [19] These bind the heavy chains in the "neck" region between the head and tail.
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