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Dabrafenib is indicated as a single agent for the treatment of people with unresectable or metastatic melanoma with BRAF V600E mutation. [2] Dabrafenib is indicated, in combination with trametinib, for BRAF V600E-positive unresectable or metastatic melanoma, metastatic non-small cell lung cancer, metastatic anaplastic thyroid cancer, and unresectable or metastatic solid tumors.
Trametinib, sold under the brand name Mekinist among others, is an anticancer medication used for the treatment of melanoma [4] [5] and glioma. [ 6 ] [ 7 ] It is a MEK inhibitor drug with anti-cancer activity. [ 8 ]
The combination of dabrafenib and trametinib was approved for NHS use for youngsters with brain tumours in April. However, Alexander has been accessing the medication privately at a cost of about ...
Braf inhibitors (vemurafenib, dabrafenib, LGX818) used to treat metastatic melanoma that harbors BRAF V600E mutation; MEK inhibitors (trametinib, MEK162) are used in experiments, often in combination with BRAF inhibitors to treat melanoma; CDK inhibitors, e.g. PD-0332991, LEE011 in clinical trials; Hsp90 inhibitors, some in clinical trials
Dabrafenib and trametinib have been approved as tissue-agnostic drugs for solid tumors that are B-RAF positive. [ 16 ] Tissue-agnostic cancer drugs that are under development as of May 2022 [update] include Selitrectinib (Loxo-195) and anti- ERBB3 antibodies.
Trametinib (GSK1120212), ... Also studied in combination with BRAF inhibitor dabrafenib to treat BRAF-mutated melanoma. In clinical trials. PD-325901, ...
Dabrafenib: Dostarlimab: Eflornithine: Elranatamab: To treat relapsed or refractory multiple myeloma after at least four lines of therapy [4] Enfortumab vedotin: Iptacopan: To treat paroxysmal nocturnal hemoglobinuria [4] Ivosidenib: Lecanemab: To treat Alzheimer's disease [4] Miglustat: Nedosiran
U0126 [1] [2] is the 'code' name for a compound associated with cancer treatment [3] and also in preventing ischemia and cellular oxidative stress. It also has likely utility in strokes and heart attacks. [4]