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Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate (ATP) to create phosphocreatine (PCr) and adenosine diphosphate (ADP). This CK enzyme reaction is reversible ...
12715 Ensembl ENSG00000104879 ENSMUSG00000030399 UniProt P06732 P07310 RefSeq (mRNA) NM_001824 NM_007710 RefSeq (protein) NP_001815 NP_031736 Location (UCSC) Chr 19: 45.31 – 45.32 Mb Chr 7: 19.14 – 19.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Creatine kinase, muscle also known as MCK, CKMM, M-CK, and CPK-M, is a creatine kinase that in humans is encoded by the MCK gene ...
Elevated creatine kinase (CK) levels in the blood (at most ~10 times normal) are typical in sIBM but affected individuals can also present with normal CK levels. Electromyography (EMG) studies display variable abnormalities such as increased insertional activity, [ 26 ] increased spontaneous activity (fibrillation potentials and sharp waves ...
Macro-creatine kinase (macro-CK) is a macroenzyme, an enzyme of high molecular weight and prolonged half-life found in human serum. [1] It is one of the most common macroenzymes. [1] Macro-CK type 1 is a complex formed by one of the creatine kinase isoenzyme types, typically CK-BB, and antibodies; typically IgG, sometimes IgA, rarely IgM.
Creatine kinase S-type, mitochondrial is an enzyme that in humans is encoded by the CKMT2 gene. [ 5 ] [ 6 ] Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine .
An elevated creatinine level is considered abnormal and may indicate decreased kidney function. [ 31 ] Blood urea nitrogen (BUN) - Also measured using a BMP or CMP , blood urea nitrogen is an indicator of how much nitrogen is in the blood at the time of the phlebotomy.
The CPK-MB test (creatine phosphokinase-MB), also known as CK-MB test, is a cardiac marker [3] used to assist diagnoses of an acute myocardial infarction, myocardial ischemia, or myocarditis. It measures the blood level of CK-MB (creatine kinase myocardial band), the bound combination of two variants (isoenzymes CKM and CKB ) of the enzyme ...
The protein encoded by this gene, CK-BB, consists of a homodimer of two identical brain-type CK-B subunits. BB-CK is a cytoplasmic enzyme involved in cellular energy homeostasis, with certain fractions of the enzyme being bound to cell membranes, ATPases, and a variety of ATP-requiring enzymes in the cell.
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