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The presence of cerebral edema, or other moderate to severe symptoms, may necessitate intravenous hypertonic saline administration with close monitoring of the serum sodium levels to avoid overcorrection. [2] SIADH was originally described in 1957 in two people with small-cell carcinoma of the lung. [3]
Nervous system problems, Cushing syndrome and SIADH (syndrome of inappropriate anti-diuretic hormone) can also be associated with small cell lung cancer. [6] Unlike extensive-stage small cell lung cancer, limited-stage small cell lung carcinoma is potentially curable. [4]
Small-cell lung carcinoma (SCLC) has long been divided into two clinicopathological stages, termed limited stage (LS) and extensive stage (ES). [8] The stage is generally determined by the presence or absence of metastases, whether or not the tumor appears limited to the thorax, and whether or not the entire tumor burden within the chest can feasibly be encompassed within a single radiotherapy ...
Symptomatic features of paraneoplastic syndrome cultivate in four ways: endocrine, neurological, mucocutaneous, and hematological.The most common presentation is a fever (release of endogenous pyrogens often related to lymphokines or tissue pyrogens), but the overall picture will often include several clinical cases observed which may specifically simulate more common benign conditions.
There are two main types of lung cancer, categorized by the size and appearance of the malignant cells seen by a histopathologist under a microscope: small cell lung cancer (SCLC; 15% of cases) and non-small-cell lung cancer (NSCLC; 85% of cases). [18] SCLC tumors are often found near the center of the lungs, in the major airways. [19]
In LEMS associated with small cell lung cancer, most have no suggestive symptoms of cancer at the time, such as cough, coughing blood, and unintentional weight loss. However, LEMS symptoms can occur up to 5 years prior to cancer diagnosis and also after cancer diagnosis. [3] LEMS associated with lung cancer may be more severe. [5]
Small-cell lung cancer [4] Ectopic Antidiuretic hormone [4] Hypercalcemia: Lung cancer (typically squamous cell) [4] Breast carcinoma [4] Renal and bladder carcinoma [4] [5] Multiple myeloma (may occur independent of osteolytic lesions) Adult T cell leukemia/lymphoma [4] Ovarian carcinoma [4] Squamous cell carcinoma (e.g., lung, head, neck ...
The incidence of bronchiolo-alveolar carcinoma has been reported to vary from 4–24% of all lung cancer patients. [23] An analysis of Surveillance epidemiology and End results registry ( SEER) by Read et al. revealed that although the incidence of BAC has increased over the past two decade it still constitutes less than 4% of NSCLC in every ...
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