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Multi-infarct dementia results from a series of small strokes affecting several brain regions. Stroke-related dementia involving successive small strokes causes a more gradual decline in cognition. [4] Dementia may occur when neurodegenerative and cerebrovascular pathologies are mixed, as in susceptible elderly people (75 years and older).
Binswanger's disease, also known as subcortical leukoencephalopathy and subcortical arteriosclerotic encephalopathy, [1] is a form of small-vessel vascular dementia caused by damage to the white brain matter. [2] White matter atrophy can be caused by many circumstances including chronic hypertension as well as old age. [3]
It is one of the most common causes of disability among the elderly but can develop before the age of 65 when it is known as early-onset dementia or presenile dementia. [ 273 ] [ 274 ] Less than 1% of those with Alzheimer's have gene mutations that cause a much earlier development of the disease, around the age of 45, known as early-onset ...
Recent research is looking at the way in which cardiovascular issue may play into the development of dementia, with one study ... from recurrent strokes caused [by] multi-infarct dementia or ...
Getting diagnosed with type 2 diabetes before the age of 50 may increase one's risk of developing dementia by 1.9 times, a new study has found. ... Vascular or multi-infarct dementia is a ...
Hachinski showed in 1975 that, in fact, only a small minority of dementias were so-caused, and that most were “multi-infarct dementias” — dementias caused by multiple, small, often imperceptible strokes. [12]
Smoking cessation is a clear modifiable risk factor for cardiovascular health and would directly decrease incidence of vascular dementia or multi-infarct dementia.
Microinfarcts may be the second most important cause of dementia, after Alzheimer's disease. [3] [4] Microinfarcts are microscopic lesions, of cellular death or tissue necrosis, which are a result of pathologies involving small vessels. Such pathologies are arteriosclerosis or cerebral amyloid angiopathy. [5]