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In the prostate, this reduces prostate volume, which improves BPH and reduces the risk of prostate cancer. Finasteride reduces prostate volume by 20 to 30% in men with benign prostatic hyperplasia. [75] Inhibition of 5α-reductase also reduces epididymal weight, and decreases motility and normal morphology of spermatozoa in the epididymis. [76]
Finasteride and Prostate Cancer Risks Finasteride has been shown to lower the overall risk of prostate cancer. However, some old research from 1993 suggested it might increase the risk of high ...
The most recent development in this line of research came in 2019 when researchers found no increase in the number of prostate cancer deaths between the group that used finasteride and a control ...
Research shows that 1mg doses of finasteride are unlikely to cause side effects and there’s no clear ... which may increase the risk of prostate cancer. Conversely, finasteride has been found to ...
They have also been explored in the treatment and prevention of prostate cancer. While the 5-ARI finasteride reduces the cancer risk by about a third, it also increases the fraction of aggressive forms of prostate cancer. Overall, there does not seem to be a survival benefit for prostate cancer patients under finasteride. [5]
Dutasteride inhibits 5α-reductase isoenzymes type 1 and 2 better than finasteride, leading to a more complete reduction in DHT at 24 weeks (94.7% versus 70.8%). [23] It also reduces intraprostatic DHT 97% in men with prostate cancer at 5 mg/day over three months. [24]
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