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Atorvastatin, sold under the brand name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. [6] For the prevention of cardiovascular disease, statins are a first-line treatment in reducing cholesterol. [ 6 ]
The exact mechanism responsible for the possible increased risk of diabetes mellitus associated with statin use is unclear. [106] However, recent findings have indicated the inhibition of HMGCoAR as a key mechanism. [110] Statins are thought to decrease cells' uptake of glucose from the bloodstream in response to the hormone insulin. [106]
[22] [23] Another consequence of taking statins is the risk of developing new-onset diabetes, which is more prominent in individuals with high TG levels and body mass index (BMI). [19] However, the risk is far outweighed by the benefits from statin therapy for the reduction in cardiovascular outcomes. [20]
Statins help lower cholesterol For this observational study, researchers analyzed data from the U.K. Biobank and Whitehall II study of more than 20,000 adults in the U.K. 70 years and older with ...
It decreases LDL by 15–30% and raises HDL by 3–5%, with little effect on triglycerides, but can cause a slight increase. Bile acid sequestrants may cause gastrointestinal problems and may also reduce the absorption of other drugs and vitamins from the gut. Ezetimibe is a selective inhibitor of dietary cholesterol absorption.
Foods with more than five ingredients would presumably be those that are processed or ultra-processed, which have been linked to cancer, heart disease, inflammation, cognitive decline, and diabetes.
According to a new study, certain diabetes medications may significantly reduce this risk. These drugs, called gliflozins or SGLT2 inhibitors, stop the kidneys from reabsorbing too much blood ...
HMG-CoA reductase is an important developmental enzyme. Inhibition of its activity and the concomitant lack of isoprenoids that yields can lead to germ cell migration defects [21] as well as intracerebral hemorrhage. [22] Homozygous mutation of HMGCR can lead to a form of limb girdle myopathy that may share features with mild statin-induced ...
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