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Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the COX enzyme. [1] This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors; aspirin creates an allosteric change in the structure of the COX enzyme. [2]
Aspirin helps prevent blood clots from forming, which is the leading cause of heart attack and stroke, but the drug also carries a risk of bleeding. That risk can outweigh aspirin’s benefits in ...
The illustration shows how PAD can affect arteries in the legs. Figure A shows a normal artery with normal blood flow. The inset image shows a cross-section of the normal artery. Figure B shows an artery with plaque buildup that is partially blocking blood flow. The inset image shows a cross-section of the narrowed artery.
You may have read or heard about various reports that taking daily aspirin—yes, that old-time resident of your grandmother's medicine cabinet—may have benefits for modern health conditions ...
For some people, aspirin does not have as strong an effect on platelets as for others, an effect known as aspirin-resistance or insensitivity. One study has suggested women are more likely to be resistant than men, [157] and a different, aggregate study of 2,930 people found 28% were resistant. [158]
In terms of environmental factors, dietary salt intake is the leading risk factor in the development of hypertension. [7] Salt sensitivity is characterized by an increase in blood pressure with an increase in dietary salt and is associated with various genetic, demographic, and physiological factors— African American populations, postmenopausal women, and older individuals carry a higher ...
Food poisoning, also known as foodborne illness, is a common sickness caused by swallowing food or liquids that contain harmful bacteria, viruses or parasites, and sometimes even chemicals.
Arteriosclerosis, literally meaning "hardening of the arteries", is an umbrella term for a vascular disorder characterized by abnormal thickening, hardening, and loss of elasticity [3] of the walls of arteries; [4] this process gradually restricts the blood flow to one's organs and tissues and can lead to severe health risks brought on by atherosclerosis, which is a specific form of ...