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Schematic of cell adhesion. Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix, a gel-like structure containing molecules released ...
Cell adhesion molecules (CAMs) are a subset of cell surface proteins [1] that are involved in the binding of cells with other cells or with the extracellular matrix (ECM), in a process called cell adhesion. [2] In essence, CAMs help cells stick to each other and to their surroundings. CAMs are crucial components in maintaining tissue structure ...
Cell junctions [1] or junctional complexes are a class of cellular structures consisting of multiprotein complexes that provide contact or adhesion between neighboring cells or between a cell and the extracellular matrix in animals. [2] They also maintain the paracellular barrier of epithelia and control paracellular transport. Cell junctions ...
L1-Cell Adhesion Molecule (L1CAM) was first discovered to be important in neuron-related tissue development in the mid-1980s, and is a trans-membranal glycoprotein of approximately 200-220 kDa. On its extracellular domain, the L1CAM protein includes IgG -like and fibronectin -III (FN-III) repeats which allow for interaction with integrins and ...
In this diagram, the interface between neighboring cells or the basolateral membrane is depicted as "sheets"; the space between these sheets being the extracellular environment and the location of adhesion protein interaction. Stable cell-cell interactions are required for cell adhesion within a tissue and controlling the shape and function of ...
Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a protein that in humans is encoded by the ICAM3 gene. [3] The protein is constitutively expressed on the surface of leukocytes, which are also called white blood cells and are part of the immune system.
The L1 cell adhesion molecule (L1CAM) is a cell surface glycoprotein found in humans (and other forms of life as mice, for example) which has a 1253 amino acid protein sequence. The extracellular portion is formed of six immunoglobulin domains followed by five fibronectin type III domains which are connected to a small intracellular domain by a ...
Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. [5] VCAM-1 functions as a cell adhesion molecule .