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The primary antidote to brodifacoum poisoning is immediate administration of vitamin K 1 (dosage for humans: initially slow intravenous injections of 10–25 mg repeated at 3–6 hours until normalisation of the prothrombin time; then 10 mg orally four times daily as a "maintenance dose"). It is an extremely effective antidote, provided the ...
Warning label on a tube of rat poison containing bromadiolone on a dike of the Scheldt river in Steendorp, Belgium. Bromadiolone is a potent anticoagulant rodenticide.It is a second-generation 4-hydroxycoumarin derivative and vitamin K antagonist, often called a "super-warfarin" for its added potency and tendency to accumulate in the liver of the poisoned organism.
Brodifacoum takes a very long time to break down in soil and water and accumulates in the tissue of exposed animals for years. Consequently, there is a very high risk of by-kill: it is known to have killed at least 21 species of native birds, including kiwi , kākā , kākāriki and tūī . [ 76 ]
Harmful algae blooms produce toxins that can poison humans, pets and wildlife, according to the Washington State Lake Protection Association. They commonly begin to occur near the start of summer ...
Harmful algae blooms produce toxins that can poison humans, pets and wildlife, according to the Washington State Lake Protection Association. They commonly begin to occur near the start of summer ...
Diphenadione is a vitamin K antagonist that has anticoagulant effects and is used as a rodenticide against rats, mice, voles, ground squirrels and other rodents. The chemical compound is an anti-coagulant with active half-life longer than warfarin and other synthetic 1,3-indandione anticoagulants.
Reason: brodifacoum is used only in biocidal (rodenticidal) context, it has no pharmacologic relevance other than its toxicity. Since the only use of it is that of a poison per se, it is appropriate to discuss its dynamics and kinetics in organism as toxodynamics and toxokinetics, forming toxicology of the substance.
Their latest research estimates that 151 million cases of psychiatric disorders—including depression, anxiety, and hyperactivity— from the past 75 years can be traced to childhood lead exposure.