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Pregnenolone is produced mainly in the adrenal glands, the gonads, and the brain. [4] Although pregnenolone is also produced in the gonads and brain, most circulating pregnenolone is derived from the adrenal cortex. [17] To assay conversion of cholesterol to pregnenolone, radiolabeled cholesterol has been used. [18]
Pregnenolone, sold under the brand name Enelone among others, is a medication and supplement as well as a naturally occurring and endogenous steroid. [3] [1] [4] [5] [6] It is described as a neurosteroid and anti-inflammatory drug and was used in the treatment of rheumatoid arthritis and soft-tissue rheumatism in the 1950s and is no longer prescribed today, but remains available as a supplement.
Pregnanolone, also known as eltanolone, is an endogenous inhibitory neurosteroid which is produced in the body from progesterone. [4] It is closely related to allopregnanolone, which has similar properties. [4]
1583 13070 Ensembl ENSG00000140459 ENSG00000288362 ENSMUSG00000032323 UniProt P05108 Q9QZ82 RefSeq (mRNA) NM_001099773 NM_000781 NM_019779 NM_001346787 RefSeq (protein) NP_000772 NP_001093243 NP_001333716 NP_062753 Location (UCSC) Chr 15: 74.34 – 74.37 Mb Chr 9: 57.91 – 57.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cholesterol side-chain cleavage enzyme is commonly ...
Pregnenolone sulfate (PS, PREGS) is an endogenous excitatory neurosteroid that is synthesized from pregnenolone. [ 1 ] [ 2 ] It is known to have cognitive and memory-enhancing , antidepressant , anxiogenic , and proconvulsant effects.
Progesterone is the major progestogen produced by the corpus luteum of the ovary in all mammalian species. Luteal cells possess the necessary enzymes to convert cholesterol to pregnenolone, which is subsequently converted into progesterone. Progesterone is highest in the diestrus phase of the estrous cycle.
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