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Loperamide taken with quinidine was found to produce respiratory depression, indicative of central opioid action. [43] High doses of loperamide have been shown to cause a mild physical dependence during preclinical studies, specifically in mice, rats, and rhesus monkeys. Symptoms of mild opiate withdrawal were observed following abrupt ...
Tolerance is a physiologic process where the body adjusts to a medication that is frequently present, usually requiring higher doses of the same medication over time to achieve the same effect. It is a common occurrence in individuals taking high doses of opioids for extended periods, but does not predict any relationship to misuse or addiction.
Fentanyl. 2 mg (white powder to the right) is a lethal dose in most people. [19] US penny is 19 mm (0.75 in) wide. Risk factors for opioid overdose include opioid dependence, injecting opioids, using high doses of opioids, and use together with alcohol, benzodiazepines, or cocaine. [1] [2] The risk is particularly high following detoxification. [1]
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
However, later on, the following is stated: Loperamide can be present in breast milk, and is not recommended for breast feeding mothers.. One of the sources may be wrong or wrongly explained in the article. Richard Wolf VI 04:29, 3 March 2018 (UTC) This is not uncommon nor a contradiction.
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