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Amphetamine base in marketed amphetamine medications drug formula molar mass [note 1] amphetamine base [note 2] amphetamine base in equal doses doses with equal base content [note 3] (g/mol) (percent) (30 mg dose) total base total dextro- levo- dextro- levo- dextroamphetamine sulfate [2] [3] (C 9 H 13 N) 2 •H 2 SO 4
Amphetamine type stimulants can be used in the treatment of narcolepsy, a rare neurological disorder where the brain is unable to regulate the sleep-wake mechanism. [17] Amphetamines causes an increase in dopamine release, which is the proposed mechanism for its wake-promoting effect. [ 18 ]
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Amphetamine [note 2] (contracted from alpha-methylphenethylamine) is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity; it is also used to treat binge eating disorder in the form of its inactive prodrug lisdexamfetamine.
Dexmedetomidine may be useful for the treatment of the negative cardiovascular effects of acute amphetamines and cocaine intoxication and overdose. [27] [28] Dexmedetomidine has also been used as an adjunct to neuroaxial anesthesia for lower limb procedures. [29] It has been successfully used to treat opioid withdrawal symptoms. [30]
The "two dogs" or "dopeboy" clandestine method, starting with helional as a precursor. First, an oxime is created using hydoxylamine. Then, a Beckmann rearrangement is performed with nickel acetate to form the amide. Then a Hofmann rearrangement is done to form the freebase amine of MDA. Then it is purified with an acid base extraction.
Amfetaminil (also known as amphetaminil, N-cyanobenzylamphetamine, [1] and AN-1; brand name Aponeuron) is a stimulant drug derived from amphetamine, which was developed in the 1970s and used for the treatment of obesity, [2] ADHD, [3] [4] and narcolepsy. [5] It has largely been withdrawn from clinical use following problems with abuse. [6]
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