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Polysulfated glycosaminoglycan (PSGAG), sold under the brand name Adequan, is an injectable drug for dogs and horses that is used to alleviate the limpness, pain, and lowered range of motion caused by arthritis. [2]
There have also been some studies which have showed anti-inflammatory properties of glucosamine which would also help joint function in aging dogs. [8] Glucosamine is usually provided in supplements in the form of glucosamine sulfate, or by the inclusion of chicken meal in the diet, as it contains glucosamine as well as chondroitin. [9] [10]
In the first study, glucosamine sulfate was given to healthy volunteers in doses of 750, 1,500, or 3,000 mg once daily. In the second study, oral glucosamine sulfate capsules (1,500 mg) were given daily for two weeks to 12 people with osteoarthritis.
Cosequin comes in formulas specific for cats, dogs and horses. [2] According to the manufacturer Cosequin may be useful for pets with osteoarthritis (OA), but the efficacy is disputed. [3] Glucosamine is used in equine medicine, but little evidence indicates that it has any value in the treatment of joint disease in horses. [4]
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Chemical structure of one unit in a chondroitin sulfate chain. Chondroitin-4-sulfate: R 1 = H; R 2 = SO 3 H; R 3 = H. Chondroitin-6-sulfate: R 1 = SO 3 H; R 2, R 3 = H.. Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) [1] composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid).
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