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U.S. Route 45 (US 45) is a major north-south United States highway and a border-to-border route, from Lake Superior to the Gulf of Mexico. A sign at the highway's northern terminus notes the total distance as 1,297 miles (2,087 km).
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U.S. Highway 45 (US 45) runs north–south through the eastern and northern portions of the state of Wisconsin. Also called Highway 45 , it runs from the state line with Illinois near the village of Bristol in Kenosha County to the Michigan state line at the town of Land O' Lakes in Vilas County , a total of about 305 miles (491 km).
U.S. Route 45 (US 45) in the state of Illinois is a major north–south U.S. Highway that runs from the Brookport Bridge over the Ohio River at Brookport north through rural sections of eastern Illinois and then through the suburbs of Chicago to the Wisconsin state line east of Antioch.
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From the Mississippi state line, US 45 extends north as a four-lane divided highway, running concurrently with unsigned State Route 5 (SR 5), to an intersection with Old US Highway 45 S (a connector to Mississippi Highway 145 [MS 145]), where it narrows to an undivided four-lane and passes through the town of Guys.
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Interstate 45 (I-45 [a]) is a major Interstate Highway located entirely within the U.S. state of Texas.While most primary Interstate routes which have numbers ending in "5" are cross-country north–south routes, I-45 is comparatively short, with the entire route located within Texas.