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High levels of prolactin during pregnancy and breastfeeding also increase insulin resistance, increase growth factor levels (IGF-1) and modify lipid metabolism in preparation for breastfeeding. During lactation, prolactin is the main factor maintaining tight junctions of the ductal epithelium and regulating milk production through osmotic balance.
Lactase persistence or lactose tolerance is the continued activity of the lactase enzyme in adulthood, allowing the digestion of lactose in milk.In most mammals, the activity of the enzyme is dramatically reduced after weaning. [1]
Lactase (EC 3.2.1.108) is an enzyme produced by many organisms and is essential to the complete digestion of whole milk. It breaks down the sugar lactose into its component parts, galactose and glucose. Lactase is found in the brush border of the small intestine of humans and other mammals.
Alpha-lactalbumin, which is expressed in response to prolactin, increases the affinity of N-acetyllactosamine synthase for its substrate, causing increased production of lactose during lactation. The interaction that facilitates lactose biosynthesis consists of a-lactalbumin (the regulatory unit) binding reversibly to the glycosyltransferase.
Women get the gene to release more than one egg through their mother and her mother and her mother…. Identical twins (one egg that splits) is random nature and can happen at any time. 5.
Lactic acidosis refers to the process leading to the production of lactate by anaerobic metabolism. It increases hydrogen ion concentration tending to the state of acidemia or low pH. The result can be detected with high levels of lactate and low levels of bicarbonate. This is usually considered the result of illness but also results from ...
The reduction of lactase production starts typically in late childhood or early adulthood, [1] but prevalence increases with age. [5] Diagnosis may be confirmed if symptoms resolve following eliminating lactose from the diet. [1] Other supporting tests include a hydrogen breath test and a stool acidity test. [1]
With an exercise intensity higher than the threshold the lactate production exceeds the rate at which it can be broken down. The blood lactate concentration will show an increase equal to 4.0 mM; it then accumulates in the muscle and then moves to the bloodstream. [2]
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