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Gabapentin is a prescription medication that was approved by the U.S. Food and Drug Administration in 1993 as a treatment for epilepsy. It works by binding to a type of calcium channel in nerve ...
Gabapentin is recommended as a first-line treatment for chronic neuropathic pain by various medical authorities. [ 10 ] [ 11 ] [ 32 ] [ 33 ] This is a general recommendation applicable to all neuropathic pain syndromes except for trigeminal neuralgia , where it may be used as a second- or third-line agent.
Gabapentin is sometimes used in an off-label capacity, meaning healthcare providers prescribe it for things the FDA (U.S. Food and Drug Administration) hasn’t approved it for.
Gabapentin, under the brand name Neurontin, was first approved in May 1993 for the treatment of epilepsy in the United Kingdom, and was marketed in the United States in 1994. [ 43 ] [ 44 ] Subsequently, gabapentin was approved in the United States for the treatment of postherpetic neuralgia in May 2002. [ 45 ]
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Gabapentin enacarbil has passed human clinical trials for the treatment of restless legs syndrome, and initial results have shown it to be well tolerated and reasonably effective. [ 6 ] [ 7 ] [ 8 ] Gabapentin enacarbil was denied approval by the U.S. Food and Drug Administration (FDA) in February 2010, citing concerns about possible increased ...
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