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Without cyclin, CDK is less active than in the cyclin-CDK heterodimer complex. [ 5 ] [ 6 ] CDKs phosphorylate proteins on serine (S) or threonine (T) residues. The specificity of CDKs for their substrates is defined by the S/T-P-X-K/R sequence, where S/T is the phosphorylation site, P is proline, X is any amino acid, and the sequence ends with ...
8621 69562 Ensembl ENSG00000065883 ENSMUSG00000041297 UniProt Q14004 Q69ZA1 RefSeq (mRNA) NM_003718 NM_031267 NM_001081058 NM_027118 RefSeq (protein) NP_003709 NP_112557 NP_001074527 NP_081394 Location (UCSC) Chr 7: 39.95 – 40.1 Mb Chr 13: 17.88 – 17.98 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin dependent kinase 13 is an enzyme that in humans is encoded by the CDK13 ...
12568 Ensembl ENSG00000164885 ENSMUSG00000028969 UniProt Q00535 P49615 RefSeq (mRNA) NM_001164410 NM_004935 NM_007668 RefSeq (protein) NP_001157882 NP_004926 NP_031694 Location (UCSC) Chr 7: 151.05 – 151.06 Mb Chr 5: 24.62 – 24.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-dependent kinase 5 is a protein, and more specifically an enzyme, that is encoded by the Cdk5 ...
The CDK4 gene is located on chromosome 12 in humans. [7] The gene is composed of 4,583 base pairs which together code for the 303 amino acid protein with a molecular mass of 33,730 Da. [7] [8] All CDK proteins, including CDK4, have two lobes: the smaller N-terminal lobe (which contains an inhibitory G-loop), and the C terminal lobe (which contains an activation domain and a T-loop).
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression.
The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or Cdk4, a serine-threonine kinase.This complex is one of many cyclin/cyclin-dependent kinase complexes that are the "hearts of the cell-cycle control system" [1] and govern the cell cycle and its progression.
Cyclin-dependent kinase inhibitor proteins work by inactivating the CDKs through degradation. The typical inactivation mechanism of the CDK/Cyclin complex is based on binding a CDK inhibitor to the CDK cyclin complex and a partial conformational rotation of the CDK. [4] The cyclin is thus forced to release the T loop and detach from the CDK.
Drift seeds (also sea beans) and drift fruits are seeds and fruits adapted for long-distance dispersal by water. Most are produced by tropical trees, and they can be found on distant beaches after drifting thousands of miles through ocean currents .