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IgG4-related disease (IgG4-RD), formerly known as IgG4-related systemic disease, is a chronic inflammatory condition characterized by tissue infiltration with lymphocytes and IgG4-secreting plasma cells, various degrees of fibrosis (scarring) and a usually prompt response to oral steroids.
IgG4-related ophthalmic disease (IgG4-ROD) is the recommended term to describe orbital (eye socket) manifestations of the systemic condition IgG4-related disease, [2] which is characterised by infiltration of lymphocytes and plasma cells and subsequent fibrosis in involved structures. It can involve one or more of the orbital structures.
Although a clear understanding of the various skin lesions in IgG4-related disease is a work in progress, skin lesions have been classified into subtypes based on documented cases: [2] Angiolymphoid hyperplasia with eosinophilia (or lesions that mimic it) [3] and cutaneous pseudolymphoma; Cutaneous plasmacytosis [Note 1]
IgG4-related autoimmune diseases are characterized by excessive fibrosis. In case of Riedel's thyroiditis, fibrosis extends beyond the capsule and involves contiguous neck structures, clinically simulating thyroid carcinoma. There is a rapid thyroid enlargement. Compression of trachea, dysphagia are probable outcomes.
IgG deficiency is a form of dysgammaglobulinemia where the proportional levels of the IgG isotype are reduced relative to other immunoglobulin isotypes.. IgG deficiency is often found in children as transient hypogammaglobulinemia of infancy, which may occur with or without additional decreases in IgA or IgM.
Michael Garron Hospital (MGH), formerly Toronto East General Hospital (TEGH), is a community teaching hospital located at 825 Coxwell Avenue in East York, Toronto, Ontario, Canada. Overview [ edit ]
The hospital now stands as the largest cancer centre in Canada [1] and one of the five largest cancer centres in the world. [2] Along with the Odette Cancer Centre , which is also associated with University of Toronto Faculty of Medicine and is independently the sixth largest cancer centre in North America, it forms one of the largest cluster ...
North York General Hospital (NYGH) is a teaching hospital in Toronto, Ontario, Canada. Primarily serving the North York district, as well as southern York Region, it offers acute care, ambulatory and long-term services at multiple sites. It is one of Canada's leading community academic hospitals and is affiliated with the University of Toronto. [1]