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Benign tumour of the submandibular gland, also known as pleomorphic adenoma, presented as a painless neck mass in a 40-year-old man. At the left of the image is the white tumour with its characteristic cartilaginous cut surface. To the right is the normally lobated submandibular salivary gland. Warthin's tumor; Myoepithelioma; Basal cell ...
The Stafne defect is thought to be a normal anatomical variant, as the depression is created by ectopic salivary gland tissue associated with the submandibular gland and does not represent a pathologic lesion as such. This cavity is commonly observed on panoramic radiograph.
However, salivary tumors show a great deal of morphological diversity, as well as variations in the nature of the lesion (malignant vs. benign): approximately 20% to 25% of parotid tumors, 35% to 40% of submandibular tumors, and more than 90% of sublingual gland tumors are malignant. [8]
The most common causes of enlargement of the submandibular lymph nodes are infections of the head, neck, ears, eyes, nasal sinuses, pharynx, and scalp. [1] The lymph glands may be affected by metastatic spread of cancers of the oral cavity, anterior portion of the nasal cavity, soft tissues of the mid-face, and submandibular salivary gland. [1]
About 85% of stones occur in the submandibular gland, [3] and 5–10% occur in the parotid gland. [2] In about 0–5% of cases, the sublingual gland or a minor salivary gland is affected. [ 2 ] When minor glands are rarely involved, caliculi are more likely in the minor glands of the buccal mucosa and the maxillary labial mucosa. [ 4 ]
[8] [9] [10] The most common form is combined cleft lip and palate and it accounts for approximately 50% of cases, whereas isolated cleft lip concerns 20% of the patients. [ 11 ] People with cleft lip and palate malformation tend to be less social and report lower self-esteem, anxiety and depression related to their facial malformation.
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM).. This list continues the information at List of MeSH codes (D20).
Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. [5]