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Other mucus-secreting cells are the mucous neck cells in the necks of the gastric glands. [2]: 257 Surface mucous cells have large quantities of mucin granules in their apical (top) surface and project short microvilli into the lumen of the stomach. [2]: 257 Mucins are large glycoproteins that give the mucus its gel-like properties. [3]
Stomach cancer, also known as gastric cancer, is a malignant tumor of the stomach. It is a cancer that develops in the lining of the stomach . [ 10 ] Most cases of stomach cancers are gastric carcinomas , which can be divided into a number of subtypes, including gastric adenocarcinomas . [ 2 ]
The first cells of all of the glands are mucus-secreting foveolar cells that line the gastric pits. The mucus produced here is less acidic than that produced by the mucous neck cells. Fundic glands found in the fundus and also in the body have another two cell types–gastric chief cells and parietal cells (oxyntic cells).
Owing to the causal relationship between H. pylori infection and gastric MALT lymphoma, identification of the infection is imperative. Histological examination of GI biopsies yields a sensitivity of 95% with five biopsies, [7] but these should be from sites uninvolved by lymphoma and the identification of the organism may be compromised by areas of extensive intestinal metaplasia.
K cells: Intestinal glands: Secretion of the hormone glucose-dependent insulinotropic peptide, which stimulates the release of insulin M cells: Intestinal glands of duodenum and jejunum: Secretion of the hormone motilin, which accelerates gastric emptying, stimulates intestinal peristalsis, and stimulates the production of pepsin S cells ...
The sodium-iodide symporter (SIP) is expressed in all the surface mucous cells (at the basolateral membrane) but not in the mucous neck cells. SIP mediates the transport of iodide from the bloodstream and secretes it into the gastric lumen where it is taken up in the gastric juice. Its role is not known but it has been shown to be absent in ...
A special mucus covering, derived from mucus secreted by surface epithelial cells and Foveolar cells. This insoluble mucus forms a protective gel-like coating over the entire surface of the gastric mucosa. The mucus protects the gastric mucosa from autodigestion by e.g. pepsin and from erosion by acids and other caustic materials that are ...
In gastric tissue, a loss of parietal cells due to chronic inflammation has been shown to affect chief cell differentiation and can induce chief cells to transdifferentiate back into neck cells and can lead to the formation of mucus cell metaplasia known as spasmolytic polypeptide expressing metaplasia (SPEM) that could be precancerous. [14]