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About one third of children whose mothers are taking this drug during pregnancy typically have intrauterine growth restriction with a small head and develop minor dysmorphic craniofacial features (microcephaly and intellectual disability) and limb defects including hypoplastic nails and distal phalanges (birth defects).
Signs and symptoms of pregnancy are common, benign conditions that result from the changes to the body that occur during pregnancy. Signs and symptoms of pregnancy typically change as pregnancy progresses, although several symptoms may be present throughout. Depending on severity, common symptoms in pregnancy can develop into complications. [1]
The genetic cause of ED lies in mutations, or changes, in certain genes that play an essential role in forming ectodermal structures. These genes are part of signalling pathways—most notably, the EDA/NF-kappaB pathway—which guide the development of hair, skin, nails, teeth, and glands during embryonic growth.
Polyonychia can also be acquired, such as after an accident that affected the nail bed causing it to split. This type of polyonychia is just referred to as "post-traumatic split nail" [3] Polyonychia's syndromic causes include: Isolated congenital onychodysplasia [4] Polyonychia's non-syndromic causes include:
Biotin deficiency is very uncommon, but experiencing it can cause an array of side effects, including: hair thinning or loss, brittle nails, a red scaly rash (around the eyes, nose, and mouth), a ...
A new nail plate will form once the cause of the disease is removed. Onychomycosis , also known as tinea unguium , is a contagious infection of the nail caused by the same fungal organisms which cause ringworm of the skin ( Trichophyton rubrum or T. mentagrophytes , rarely other trichophyton species or Epidermophyton floccosum [ 1 ] ).
The increase in kidney clearance during pregnancy causes more iodide to be excreted and causes relative iodine deficiency and as a result an increase in thyroid size. Estrogen-stimulated increase in thyroid-binding globulin (TBG) leads to an increase in total thyroxine (T4), but free thyroxine (T4) and triiodothyronine (T3) remain normal.
Trauma to the nail plate or toe, which can occur by dropping objects on or stubbing the toenail, or by the nail protruding through the shoe (as during sports or other vigorous activity), can cause the flesh to become injured and the nail to grow irregularly and press into the flesh.