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TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. [5] It is encoded by the TBK1 gene in humans. [6] This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity. [5]
Upon activation, STING stimulates TBK1 activity to phosphorylate IRF3 or STAT6. Phosphorylated IRF3s and STAT6s dimerize, and then enter nucleus to stimulate expression of genes involved in host immune response, such as IFNB, CCL2, CCL20, etc. [8] [23] Several reports suggested that STING is associated with the activation of selective autophagy ...
TBK1 may refer to: TANK-binding kinase 1, an enzyme; IkappaB kinase, an enzyme This page was last edited on 30 December 2019, at 15:16 (UTC). Text is available under ...
Former President Barack Obama's family was the subject of a recent article stating a man had filed a lawsuit claiming he was the biological father of Obama's daughters, Sasha and Malia.
56489 Ensembl ENSG00000263528 ENSMUSG00000042349 UniProt Q14164 Q9R0T8 RefSeq (mRNA) NM_001193321 NM_001193322 NM_014002 NM_019777 RefSeq (protein) NP_001180250 NP_001180251 NP_054721 NP_062751 Location (UCSC) Chr 1: 206.47 – 206.5 Mb Chr 1: 131.18 – 131.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Inhibitor of nuclear factor kappa-B kinase subunit epsilon also known as I ...
Clifford Smith, Jr. [3] (born March 2, 1971), [4] better known by his stage name Method Man, is an American rapper, record producer, and actor. He is a member of the East Coast hip hop collective Wu-Tang Clan, and is half of the hip hop duo Method Man & Redman. He took his stage name from the 1979 film Method Man. [5]
The elder brother of Ertuğrul Gazi and Dündar Bey, younger half-brother of Gündoğdu Bey. Osman Bey's uncle. Has a son and a daughter with an unknown wife. He works as a spy for the white bearded in the Margret monks under a fake name Hristo. In Season 2 he is said to have been killed by the Byzantine emperor in unknown circumstances.
Popular comedian and YouTube personality with the alter egos of Filthy Frank and Pink Guy, who has retired. Currently, he is a musician, under the name Joji, with songs and albums charting. Max Miller: United States Tasting History with Max Miller