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2'-O-methylation (2'-O-Me) is a common nucleotide epitranscriptomics modification of ribosomal RNA (rRNA). The rRNA is transcribed from DNA and then used to create proteins through translation. [ 1 ] The resulting protein would normally be solely dependent on the gene it was translated from, but the methylation of the RNA would influence the ...
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] SNORD99 is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA at residue A2774. [2] In the human genome this snoRNA shares the same host gene with the three H/ACA box snoRNAs ACA16, ACA44 and ACA61. [2]
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] snoRNA U79 is found in intron 7 of the GAS5 gene in humans and is also present in mice. [2] U79 is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) residue A3809. [3]
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [ 1 ] U73 is encoded within the introns of ribosomal protein S3a and contains a 12 nucleotide region of complementarity to a conserved sequence in 28S ribosomal RNA (rRNA). [ 2 ]
[2] [3] Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. HBII-99 is predicted to guide the 2'O-ribose methylation of 28S rRNA G3878. [4] U106 contains conserved antisense elements which would predict U106 methylates residues G1536 and U1602 of 18S rRNA. [5]
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This snoRNA is the human orthologue of mouse snoRNA MBII-336. [2] SNORD93 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue A576. [ 3 ] Additionally, SNORD93 can be processed into a smaller, microRNA-like fragment (termed snoRNA-derived RNA(sdRNA)) that contributes to the malignant phenotype of breast cancer ...
Most of the members of the box C/D family function in directing site-specific 2′-O-methylation of substrate RNAs. [1] HBII-55 is predicted to guide the 2′O-ribose methylation of 18S ribosomal RNA (rRNA) at residue U1288.