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TMP/SMX is commonly used due to its ability to achieve high concentrations in urinary tract tissues and urine. This antibiotic combination demonstrates notable efficacy in both the treatment and prophylaxis of recurrent urinary tract infections. [12] Common adverse effects include nausea, vomiting, rash,pruritus, and photosensitivity. [26]
Vancomycin is a glycopeptide antibiotic medication used to treat certain bacterial infections. [7] It is administered intravenously (injection into a vein) to treat complicated skin infections, bloodstream infections, endocarditis, bone and joint infections, and meningitis caused by methicillin-resistant Staphylococcus aureus. [8]
In other words, it is the ratio of amount of drug in a body (dose) to concentration of the drug that is measured in blood, plasma, and un-bound in interstitial fluid. [3] [4] The V D of a drug represents the degree to which a drug is distributed in body tissue rather than the plasma.
For bacterial or viral agents, dose typically refers to the amount of the pathogen required to infect a host. In clinical pharmacology , dose refers to the amount of drug administered to a person, and dosage is a fuller description that includes not only the dose (e.g., "500 mg") but also the frequency and duration of the treatment (e.g ...
After the discovery and commercialization of antibiotics, microbiologist, pharmacologist, and physician Alexander Fleming developed the broth dilution technique using the turbidity of the broth for assessment. [11] This is commonly believed to be the conception point of minimum inhibitory concentrations. [12]
There are also strains of enterococci that have developed resistance to vancomycin referred to as vancomycin resistant enterococcus (VRE). Agents classified as fourth-line (or greater) treatments or experimental therapies could be considered by default to be drugs of last resort due to their low placement in the treatment hierarchy.
Routes of administration are usually classified by application location (or exposition). The route or course the active substance takes from application location to the location where it has its target effect is usually rather a matter of pharmacokinetics (concerning the processes of uptake, distribution, and elimination of drugs).
continue same treatment cuj. cujus: of which c.v. cras vespere: tomorrow evening cyath. cyathus: a glassful cyath. vinos. cyathus vinosus: a wine-glassful D, d. die [or] dosis: days [or] doses: ambiguous meaning, write out "days" or "doses" D5LR dextrose 5% in lactated Ringer's solution (intravenous sugar solution) D5NS
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