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Other risks include kidney stones. [11] Doses greater than 40 000 IU (1000 μg) per day are generally required before high blood calcium occurs. [12] Normal doses, 800–2000 IU per day, are safe in pregnancy. [5] Cholecalciferol was first described in 1936. [13] It is on the World Health Organization's List of Essential Medicines. [14]
In that study, the compliance calculation could be questionable since only random samples of the returned medications were counted. In a study by De Niet et al., [72] 60 subjects with vitamin D deficiency were randomized to receive 2000 IU vitamin D3 daily or 50 000 IU monthly. They reported a similar efficacy of the two dosing frequencies ...
While some studies have found that vitamin D 3 raises 25(OH)D blood levels faster and remains active in the body longer, [44] [45] others contend that vitamin D 2 sources are equally bioavailable and effective for raising and sustaining 25(OH)D. [46] [47] If digestive disorders compromise absorption, then intramuscular injection of up to ...
Vitamin D3, aka cholecalciferol, is important for bone health and immune function. Experts discuss benefits, sources, risks and who needs a supplement.
There's lots of confusion around the difference between vitamin D2 and vitamin D3, and which is best for whom. Doctors and experts explain.
Vitamin D compounds, specifically cholecalciferol (D3) and ergocalciferol (D2), are used in rodenticides due to their ability to induce hypercalcemia, a condition characterized by elevated calcium levels in the blood. This overdose leads to organ failure and is pharmacologically similar to vitamin D's toxic effects in humans.
At a typical intake of cholecalciferol (up to 2000 IU/day), conversion to calcifediol is rapid. When large doses are given (100,000 IU), it takes 7 days to reach peak calcifediol concentrations. [9] Calcifediol binds in the blood to vitamin D-binding protein (also known as gc-globulin) and is the main circulating vitamin D metabolite.
Calcitriol is a hormone and the active form of vitamin D, normally made in the kidney. [8] [9] [10] It is also known as 1,25-dihydroxycholecalciferol.It binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [11]
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