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Signs of folate deficiency anemia most of the time are subtle. [4] Anemia (macrocytic, megaloblastic anemia) can be a sign of advanced folate deficiency in adults. [1] Folate deficiency anemia may result in feeling tired, weakness, changes to the color of the skin or hair, open sores on the mouth, shortness of breath, palpitations, lightheadedness, cold hands and feet, headaches, easy bleeding ...
Much of the elder population take supplements that add 400 μg to their daily folic acid intake. This is a concern because 70–80% of the population have detectable levels of unmetabolized folic acid in their blood , a consequence of folic acid supplementation and fortification. [ 47 ]
The National Institutes of Health recommends that the average man consume a mere 2.4 micrograms a day, which is actually the lowest daily recommended dose of any vitamin. “Vitamin B12 ...
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Because water-soluble B vitamins are eliminated in the urine, taking large doses of certain B vitamins usually only produces transient side effects (only exception is pyridoxine). General side effects may include restlessness, nausea and insomnia. These side effects are almost always caused by dietary supplements and not foodstuffs.
Compared to them, the mortality rate was 4% higher for those who took multivitamins daily and 9% higher for those who took them less often. Younger vitamin users had the highest risk.
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