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Protease inhibitors were the second class of antiretroviral drugs developed. The first members of this class, saquinavir , ritonavir , and indinavir , were approved in late 1995–1996. Within 2 years, annual deaths from AIDS in the United States fell from over 50,000 to approximately 18,000 [ 5 ] Prior to this the annual death rate had been ...
Statins, also known as beta-hydroxy-beta-methylglutaryl-Coenzyme A (HMG-CoA) reductase inhibitors, are the first-line drugs for hypercholesterolaemia. [19] Examples of this drug class are atorvastatin, rosuvastatin, fluvastatin, simvastatin, pravastatin and lovastatin.
The U.S. Food and Drug Administration (FDA) notified healthcare professionals of updates to the prescribing information concerning interactions between protease inhibitors and certain statin drugs. Protease inhibitors and statins taken together may increase the blood levels of statins and increase the risk for muscle injury (myopathy).
Statins are medications that can lower cholesterol by reducing the body's production of the substance. They can also help reduce triglycerides and raise HDL cholesterol. They can also help reduce ...
SARS-CoV-2 main protease inhibitors (12 P) Serine protease inhibitors (36 P) Pages in category "Protease inhibitors"
Statins, or inhibitors of HMG-CoA reductase. Pages in category "Statins" The following 23 pages are in this category, out of 23 total.
Risk factors for statin induced rhabdomyolysis include older age, renal impairment, high dose statins and use of medications that reduce the breakdown of statins (such as CYP3A4 inhibitors) or fibrates. [66] Persistent liver enzyme abnormalities (usually elevated in hepatic transaminases) have been documented. [67]
Additional medications for high cholesterol such as clofibrate, fenofibrate, gemfibrozil, and niacin (when taken in lipid-modifying doses of 1 g/day and above) Specific protease inhibitors including atazanavir (when taken with ritonavir), lopinavir/ritonavir and simeprevir
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