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Since gestational choriocarcinoma (which arises from a hydatidiform mole) contains paternal DNA (and thus paternal antigens), it is exquisitely sensitive to chemotherapy. The cure rate, even for metastatic gestational choriocarcinoma, is more than 90% when using chemotherapy for invasive mole and choriocarcinoma. [7]
1956 – Metastatic choriocarcinoma cancer is cured with the antifolate, methotrexate [4] 1956 – First bone marrow transplantation performed by E. Donnall Thomas in order to treat leukemia in one of two identical twins, the healthy twin being the donor [17]
Micrograph showing a colorectal carcinoma metastasis to the cerebellum. HPS stain. A brain metastasis is a cancer that has metastasized (spread) to the brain from another location in the body and is therefore considered a secondary brain tumor. [1] [2] The metastasis typically shares a cancer cell type with the original site of the cancer. [3]
Brain metastasis can be single or multiple and involve any portion of the brain. Metastasis to dural structures generally occurs by hematogenous spread or direct invasion from a contiguous bone. Dural metastases can invade the underlying brain and cause focal edema and associated neurologic symptoms. These processes tend to cause seizures early ...
Bone metastasis, or osseous metastatic disease, is a category of cancer metastases that result from primary tumor invasions into bones. Bone-originating primary tumors such as osteosarcoma , chondrosarcoma , and Ewing sarcoma are rare; the most common bone tumor is a metastasis. [ 1 ]
A micrograph showing a choriocarcinoma spread to the lung [13] Choriocarcinomas are exceptionally rare which account for 2.1%-3.4% of all OGCTs. [ 14 ] Under gross examination, the syncytiotrophoblast cells are aligned in a plexiform arrangement with the mononucleated cytotrophoblast cells surrounding the foci of the hemorrhage. [ 1 ]
The survival rate following treatment with chemotherapy is approximately at least 90%. [4] If gestational choriocarcinoma has spread to the liver in an individual, survival rate may be lower. [7] Overall survival rate is also higher when management of gestational choriocarcinoma occurs in a setting with physicians familiar with the condition.
Bone tumors may be classified as "primary tumors", which originate in bone or from bone-derived cells and tissues, and "secondary tumors" which originate in other sites and spread (metastasize) to the skeleton. Carcinomas of the prostate, breasts, lungs, thyroid, and kidneys are the carcinomas that most commonly metastasize to bone. Secondary ...