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There is some controversy as to whether these cancer cells travel through the ductal system of the breast to the nipple, [9] or whether these cells result from in situ malignant transformation. [ 2 ] The most widely accepted theory of how Paget's disease of the breast arises is the migratory theory: ductal carcinoma in situ cancerous cells ...
Triple-negative breast cancer comprises 15–20% of all breast cancer cases [3] and affects more young women or women with a mutation in the BRCA1 gene than other breast cancers. [4] Triple-negative breast cancers comprise a very heterogeneous group of cancers. TNBC is the most challenging breast cancer type to treat. [5]
This is an accepted version of this page This is the latest accepted revision, reviewed on 2 January 2025. Cancer that originates in mammary glands Medical condition Breast cancer An illustration of breast cancer Specialty Surgical Oncology Symptoms A lump in a breast, a change in breast shape, dimpling of the skin, fluid from the nipple, a newly inverted nipple, a red scaly patch of skin on ...
Breast lump, breast tumor: A breast lump associated with an inverted nipple and skin dimpling. Underlying cause was breast cancer. Specialty: Gynecology, General Surgery: Symptoms: An area of the breast that feel different than the surrounding tissue [1] Causes: Fibrocystic change, fibroadenomas, breast infection, galactoceles, breast cancer [1 ...
The prognosis of the most common form of invasive carcinoma NST is intermediate. Regardless of the histological subtype, the prognosis of IDC depends also on tumor size, presence of cancer in the lymph nodes, histological grade, presence of cancer in small vessels (vascular invasion), expression of hormone receptors and of oncogenes like HER2/neu.
The four types of PCB are defined and diagnosed in part by several of their microscopic features including: 1) the presence of tumor invasion into adjacent normal tissues; 2) the presence and location of myoepithelial cells, i.e. cells that normally rest on the basement membrane of mammary gland ducts and function to contract and thereby expel ...
The prognosis of phyllodes tumor is good with an overall 87% 10-year survival rate. [5] After wide-margin surgical excision, 98.7% of benign phyllodes tumors and 80% of borderline were cured. [25] In rare cases where the tumor has metastasized, the prognosis is poor. [5] This most commonly occurs in cases of malignant grade phyllodes tumor. [5]
This parameter assesses what percent of the tumor forms normal duct structures. In cancer, there is a breakdown of the mechanisms that cells use to attach to each other and communicate with each other, to form tissues such as ducts, so the tissue structures become less orderly. Note: The overall appearance of the tumor has to be considered. [20]