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Griffith's experiment discovering the "transforming principle" in Streptococcus pneumoniae (pneumococcal) bacteria. Griffith's experiment, [1] performed by Frederick Griffith and reported in 1928, [2] was the first experiment suggesting that bacteria are capable of transferring genetic information through a process known as transformation.
Louis Pasteur ForMemRS (/ ˈ l uː i p æ ˈ s t ɜːr /, French: [lwi pastœʁ] ⓘ; 27 December 1822 – 28 September 1895) was a French chemist, pharmacist, and microbiologist renowned for his discoveries of the principles of vaccination, microbial fermentation, and pasteurization, the last of which was named after him.
Heinrich Hermann Robert Koch (/ k ɒ x / KOKH; [1] [2] German: [ˈʁoːbɛʁt ˈkɔx] ⓘ; 11 December 1843 – 27 May 1910) was a German physician and microbiologist.As the discoverer of the specific causative agents of deadly infectious diseases including tuberculosis, cholera and anthrax, he is regarded as one of the main founders of modern bacteriology.
c. 610 – 547 BC – The Greek philosopher Anaximander extends the idea of law from human society to the physical world, and is the first to use maps and models. [7] c.400 BC – In China, the philosopher Mozi founds the Mohist school of philosophy and introduces the 'three-prong method' for testing the truth or falsehood of statements. [8]
Hyder, Avery, MacLeod and McCarty used strands of purified DNA such as this, precipitated from solutions of cell components, to perform bacterial transformations. The Avery–MacLeod–McCarty experiment was an experimental demonstration by Oswald Avery, Colin MacLeod, and Maclyn McCarty that, in 1944, reported that DNA is the substance that causes bacterial transformation, in an era when it ...
Genetic engineering has been used to produce proteins derived from humans and other sources in organisms that normally cannot synthesize these proteins. Human insulin-synthesising bacteria were developed in 1979 and were first used as a treatment in 1982. [58] In 1988 the first human antibodies were produced in plants. [59]
The experiment continues to this day, and is now the longest-running (in terms of generations) controlled evolution experiment ever undertaken. [citation needed] Since the inception of the experiment, the bacteria have grown for more than 60,000 generations. Lenski and colleagues regularly publish updates on the status of the experiments. [42]
The evolution of bacteria has progressed over billions of years since the Precambrian time with their first major divergence from the archaeal/eukaryotic lineage roughly 3.2-3.5 billion years ago. [1] [2] This was discovered through gene sequencing of bacterial nucleoids to reconstruct their phylogeny.