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The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells . DAB1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain and during adult neurogenesis .
The spontaneous autosomal recessive scrambler mutation on chromosome 4 causes a deficiency of DAB1, encoding disabled-1, a protein involved in the signaling of the Reelin protein, lacking in the reeler mutant, [3] Dab1-scm homozygous mutants possess a reeler-like phenotype with respect to cell malpositioning in cerebellar cortex, hippocampus, and neocortex.
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain.
5649 19699 Ensembl ENSG00000189056 ENSMUSG00000042453 UniProt P78509 Q60841 RefSeq (mRNA) NM_173054 NM_005045 NM_011261 NM_001310464 RefSeq (protein) NP_005036 NP_774959 NP_001297393 NP_035391 Location (UCSC) Chr 7: 103.47 – 103.99 Mb Chr 5: 22.09 – 22.55 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Reelin, encoded by the RELN gene, is a large secreted extracellular matrix ...
BBC Radio 1 Anthems is a British online-only radio stream, owned and operated by the BBC and run as a spin-off from BBC Radio 1. The station launched on 8 November 2024 and plays a wide range of music and acts supported by the main Radio 1 network in the 2000s and 2010s. [ 2 ]
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The House voted on Tuesday to pass a GOP-led bill that would ban transgender athletes from women’s and girls’ sports at federally funded schools and educational institutions.
The first to broadcast was BBC Radio 5 Live Olympics Extra in 2012, then BBC Radio 2 Eurovision launched for the first time in 2014, and was joined by BBC Radio 2 Country, BBC Music Jazz in 2015 and BBC Radio 2 50s in April 2016. When these temporary stations are on air, there is normally a reduction in bit rate of their parent station.