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Zonisamide is an antiseizure drug chemically classified as a sulfonamide and unrelated to other antiseizure agents. The precise mechanism by which zonisamide exerts its antiseizure effect is unknown, although it is believed that the drug blocks sodium and T-type calcium channels , which leads to the suppression of neuronal hypersynchronization ...
Ziconotide was discovered in the early 1980s by University of Utah research scientist Michael McIntosh, [3] when he was barely out of high school and working with Baldomero Olivera. [ 4 ] Ziconotide was developed into an artificially manufactured drug by Elan Corporation.
Using cloned α 1 G, α 1 H, and α 1 I T-type calcium channels, Gomora's team found that ethosuximide blocked the channels with an IC 50 of 12 ± 2 mmol/L and that of N-desmethylmethsuximide (the active metabolite of mesuximide) is 1.95 ± 0.19 mmol/L for α 1 G, 1.82 ± 0.16 mmol/L for α 1 I, and 3.0 ± 0.3 mmol/L for α 1 H. It was ...
All Preschools in Singapore are required to obtain license under the Early Childhood Development Centres Act 2017. [4]The Early Childhood Development Agency (ECDA), an autonomous agency jointly overseen by the Ministry of Education (MOE) and the Ministry of Social and Family Development (MSF), and hosted under the Ministry of Social and Family Development, serves as the regulatory and ...
The Integrated Programme (IP) is a 6-year programme that allows students who perform well in the Primary School Leaving Examination (PSLE) to skip the Singapore-Cambridge GCE Ordinary Level (O-level) examination, and proceed directly to a Junior College to sit for the Singapore-Cambridge GCE Advanced Level (A-level) examination, International ...
Tiki, a 20-year-old blind cat from New England, was rescued by Good Samaritans after floating on a piece of ice on a Massachusetts lake and falling in on Dec. 16, 2024.
[5] [6] In 2008, it opened its first preschool in Singapore. [5] [7] It subsequently expanded its number of schools through a mix of company-owned, company operated centres, and as well as franchising. [7] In 2019, the company was the subject of a book The MindChamps Way by New York Times and Wallstreet Journal bestselling author Dr Joseph A ...
However, the rates of immigrants into Singapore after the 1990s raised concerns and discontent among citizens, and curbs on immigration were introduced, resulting in a more stringent immigration policy since the 2010s. [1] In 2022, the government introduced a points-based immigration system for skilled applicants who wish to work in Singapore. [2]