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High-altitude pulmonary edema (HAPE) is a life-threatening form of non-cardiogenic pulmonary edema that occurs in otherwise healthy people at altitudes typically above 2,500 meters (8,200 ft). [2] HAPE is a severe presentation of altitude sickness .
Once above approximately 3,000 metres (10,000 ft) – a pressure of 70 kilopascals (0.69 atm) – most climbers and high-altitude trekkers take the "climb-high, sleep-low" approach. For high-altitude climbers, a typical acclimatization regimen might be to stay a few days at a base camp , climb up to a higher camp (slowly), and then return to ...
It is primarily used for treating severe cases of altitude sickness, [2] [3] high-altitude cerebral edema, and high-altitude pulmonary edema. [4] Like office-based hyperbaric medicine, the Gamow bag uses increased partial pressure of oxygen for therapy of hypobaric injury but has the advantage of portability for field use.
Even when acclimatized, prolonged exposure to high altitude can interfere with pregnancy and cause intrauterine growth restriction or pre-eclampsia. [28] High altitude causes decreased blood flow to the placenta, even in acclimatized women, which interferes with fetal growth. [28]
Hypobaric chamber at the Biopol'H, in Catalonia (), used with patients and athletes who need treatment or training with reduced atmospheric pressure. A hypobaric chamber, or altitude chamber, is a chamber used during aerospace or high terrestrial altitude research or training to simulate the effects of high altitude on the human body, especially hypoxia (low oxygen) and hypobaria (low ambient ...
The standard drug treatment of dexamethasone does not alter the hypoxia or the consequent vasoconstriction, but stimulates fluid reabsorption in the lungs to reverse the edema. Additionally, several studies on native populations remaining at high altitudes have demonstrated to varying degrees the blunting of the HPV response. [9]
Chronic mountain sickness (CMS) is a disease in which the proportion of blood volume that is occupied by red blood cells increases (polycythaemia) and there is an abnormally low level of oxygen in the blood . CMS typically develops after extended time living at high altitude (over 2,500 metres (8,200 ft)).
These hypoxia-related illnesses include acute mountain sickness (AMS), high-altitude pulmonary edema, and high-altitude cerebral edema (HACE). [6] High-altitude cerebral edema is a severe and sometimes fatal form of altitude sickness that results from capillary fluid leakage due to the effects of hypoxia on the mitochondria -rich endothelial ...
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