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  2. Haemophilia A - Wikipedia

    en.wikipedia.org/wiki/Haemophilia_A

    Joint capsule. Haemophilia A's phenotype has a quite wide range of symptoms encompassing both internal and external bleeding episodes. Individuals with more severe haemophilia tend to experience more intense and frequent bleeding, whereas those with mild haemophilia typically exhibit milder symptoms unless subjected to surgical procedures or significant trauma.

  3. Acquired haemophilia - Wikipedia

    en.wikipedia.org/wiki/Acquired_haemophilia

    Acquired haemophilia A (AHA) is a rare but potentially life-threatening bleeding disorder characterized by autoantibodies directed against coagulation factor VIII.These autoantibodies constitute the most common spontaneous inhibitor to any coagulation factor and may induce spontaneous bleeding in patients with no previous history of a bleeding disorder.

  4. FDA Approves Pfizer's Second Hemophilia Drug With Six Months

    www.aol.com/fda-approves-pfizers-second...

    Hemophilia is a family of rare genetic blood diseases caused by a clotting factor deficiency (FVIII in hemophilia A, FIX in hemophilia B), impacting more than 800,000 people globally.

  5. Concizumab - Wikipedia

    en.wikipedia.org/wiki/Concizumab

    Concizumab, sold under the brand name Alhemo, is a monoclonal antibody used for the treatment of hemophilia A and hemophilia B. [5] [8] It is an anti-tissue factor pathway inhibitor. [5] [8] The most common adverse reactions include injection site reactions and hives (urticaria). [11]

  6. Regeneron, Intellia Expand Partnership To Develop Hemophilia ...

    www.aol.com/news/regeneron-intellia-expand...

    Regeneron Pharmaceuticals, Inc (REGN) and Intellia Therapeutics, Inc. (NTLA) announced an expansion of their partnership to jointly develop potential products for the treatment of hemophilia A and ...

  7. The most expensive drug in the world has a $3.5 million price ...

    www.aol.com/news/most-expensive-drug-world-just...

    Patients with the blood disorder hemophilia told Insider they're excited about the new gene therapy but worried over the $3.5 million price.

  8. Haemophilia - Wikipedia

    en.wikipedia.org/wiki/Haemophilia

    The best results have been found in haemophilia B. [17] In 2016 early stage human research was ongoing with a few sites recruiting participants. [17] In 2017 a gene therapy trial on nine people with haemophilia A reported that high doses did better than low doses. [86] [87] It is not currently an accepted treatment for haemophilia. [16]

  9. Emicizumab - Wikipedia

    en.wikipedia.org/wiki/Emicizumab

    Emicizumab, sold under the brand name Hemlibra, is a humanized bispecific monoclonal antibody for the treatment of haemophilia A, developed by Genentech and Chugai (both organizations are subsidiaries of Hoffmann-La Roche). [4] A Phase I clinical trial found that it was well tolerated by healthy subjects. [5]

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