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Bromocriptine, originally marketed as Parlodel and subsequently under many brand names, [1] is an ergoline derivative and dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease, hyperprolactinaemia, neuroleptic malignant syndrome, and, as an adjunct, type 2 diabetes.
Bromocriptine is a D 2 receptor agonist and D 1 receptor antagonist with a binding affinity to D 2 receptors of anterior pituitary cells, exclusively on lactotrophs. Bromocriptine stimulates Na + , K + -ATPase activity and/or cytosolic Ca 2+ elevation and therefore reduction of prolactin which leads to no production of cAMP.
Prolactin inhibitors are mainly used to treat hyperprolactinemia (high prolactin levels). [1] Agonists of the dopamine D 2 receptor such as bromocriptine and cabergoline are able to strongly suppress pituitary prolactin secretion and thereby decrease circulating prolactin levels, and so are most commonly used as prolactin inhibitors. [1]
MoffettNathanson downgraded the world's largest company from "neutral" and set a $188 price target, representing a 22% downside from current levels. According to Bloomberg data, of the more than ...
The full mechanism of action for the anti-inflammatory effects of SSRIs is not fully known. However, there is evidence for various pathways to have a hand in the mechanism. One such possible mechanism is the increased levels of cyclic adenosine monophosphate (cAMP) as a result of interference with activation of protein kinase A (PKA), a cAMP ...
Still, Trump's nomination of Scott Bessent to the top Treasury post raised hopes that tariffs will be more measured. And with only 21 trading days left in the year, analysts, investors, and market ...
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Cover outside water spigots. Before the temperature drops below 32 degrees, outdoor water spigots attached to homes should be opened to allow to drain water out, closed and then covered.