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  2. Plateau principle - Wikipedia

    en.wikipedia.org/wiki/Plateau_Principle

    The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action (pharmacokinetics). [1] The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry, and system dynamics.

  3. Pharmacodynamics - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics

    The effects can include those manifested within animals (including humans), microorganisms, or combinations of organisms (for example, infection). Pharmacodynamics and pharmacokinetics are the main branches of pharmacology , being itself a topic of biology interested in the study of the interactions of both endogenous and exogenous chemical ...

  4. Area under the curve (pharmacokinetics) - Wikipedia

    en.wikipedia.org/wiki/Area_under_the_curve...

    In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body. [2]

  5. Pharmacokinetics - Wikipedia

    en.wikipedia.org/wiki/Pharmacokinetics

    For example, steady-state concentrations of drugs eliminated mostly by the kidney are usually greater in patients with kidney failure than they are in patients with normal kidney function receiving the same drug dosage. Population pharmacokinetics seeks to identify the measurable pathophysiologic factors and explain sources of variability that ...

  6. Drug action - Wikipedia

    en.wikipedia.org/wiki/Drug_action

    The action of drugs on the human body (or any other organism's body) is called pharmacodynamics, and the body's response to drugs is called pharmacokinetics. The drugs that enter an individual tend to stimulate certain receptors, ion channels, act on enzymes or transport proteins. As a result, they cause the human body to react in a specific way.

  7. Cmax (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Cmax_(pharmacology)

    C max is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose. [1] It is a standard measurement in pharmacokinetics.

  8. PK/PD model - Wikipedia

    en.wikipedia.org/wiki/PK/PD_model

    Explore the concept of PK/PD models, which integrate pharmacokinetics and pharmacodynamics to optimize drug dosing and efficacy.

  9. Peak-to-trough ratio - Wikipedia

    en.wikipedia.org/wiki/Peak-to-trough_ratio

    Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...